The mini ITX form factor has been gaining some serious street cred as of late. Of course, it was only a matter of time, with advances in technology leading to increasingly smaller parts that are much more powerful than their sizes suggest. The newest tiny treat for mini ITX builders is the Asus GeForce GTX 970 DC Mini, a small form factor graphics card that willl be right at home in your mini ITX motherboard.
That's kind of cool! I have an Asus Gene VII, which is mATX in a Fractal Design Node 804 case (cube style). While it has enough room for a full-sized GPU, it's rather tight.